CCAM type 1 (60-70%) (bronchial) (neonates and infants, resectable, good prognosis, possible carcinomatous change)

Synopsis

 60-70%
 bronchial type
 neonates and infants
 resectable
 good prognosis
 possible carcinomatous change (bronchioloalveolar carcinoma)
 1 or more large cysts measuring 2-10 cm in diameter
 larger cysts are often accompanied by smaller cysts
 cyst walls containing muscle, elastic, or fibrous tissue
 cysts frequently lined by pseudostratified columnar epithelial cells often interspersed with rows of mucous cells
 focal mucous cell hyperplasia (12 to 25% of type 1 CCAM)
 microscopic foci of bronchioloalveolar carcinoma (1 to 31% of type 1 CCAM) (#12883247#)

References

 MacSweeney F, Papagiannopoulos K, Goldstraw P, Sheppard MN, Corrin B, Nicholson AG. An assessment of the expanded classification of congenital cystic adenomatoid malformations and their relationship to malignant transformation. Am J Surg Pathol. 2003 Aug;27(8):1139-46. PMID: #12883247#