Autoimmune hemolytic anemia (AIHA) with giant cell hepatitis (GCH) is an uncommon disease in children and is associated with an aggressive and often fatal course.

Synopsis

 autoimmune hemolytic anemia (AIHA)
 postinfantile giant cell hepatitis

• diffuse giant cell hepatocyte transformation
• lobular architecture distortion
• portal inflammation
• portal fibrosis
• lobular pericellular fibrosis
• micronodular cirrhosis

 hemophagocytosis (#11345187#)
 Evans syndrome

See also

 Hepatitis

• autoimmune hepatitis
• giant cell hepatitis

References

 Perez-Atayde AR, Sirlin SM, Jonas M. Coombs-positive autoimmune hemolytic anemia and postinfantile giant cell hepatitis in children. Pediatr Pathol. 1994 Jan-Feb;14(1):69-77. PMID: #8159622#

 Bernard O, Hadchouel M, Scotto J, Odievre M, Alagille D. Severe giant cell hepatitis with autoimmune hemolytic anemia in early childhood. J Pediatr. 1981 Nov;99(5):704-11. PMID: #7299542#