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GDIs

GDP dissociation inhibitors

 

The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function.

GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside.

Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzymes that exert GDI displacement activity.

References

-  Dermardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol. 2005 May 23 PMID: #15921909#



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