The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function.
GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside.
Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzymes that exert GDI displacement activity.
References
Dermardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol. 2005 May 23 PMID: #15921909#