Classification

 disorders of carbohydrate metabolism
 disorders of glycoprotein
 disorders of glycolipids
 endoplasmic reticulum storage diseases
 disorders of amino acids metabolism
 peroxsomal disorders
 mitochondrial cytopathies
 disorders of porphyrin metabolism
 disorders of metals metabolism
 disorders of bile acid metabolism
 disorders of bilirubin metabolism
 miscellaneous metabolic disorders of the liver

Lesional patterns

 hepatitic pattern
 cholestatic pattern

• alpha-1-antitrypsin deficiency
• Niemann-Pick diseases type C

 ductopenic pattern

• alpha1-antitrypsin deficiency
• inborn errors of bile acid metabolism
• peroxisomal diseases (cerebrohepatorenal syndrome, Zellweger syndrome)
• coprostanic acidemia
• Byler disease
• cystic fibrosis

 steatotic pattern

• inherited metabolic diseases
  • hereditary fructose intolerance
  • galactosemia
  • glycogen storage disease type I (GSD1)
  • glycogen storage disease type II (GSD2)

• Wolman disease
• cholesterol ester storage disease
• mitochondrial respiratory chain diseases
• fatty acid oxydation diseases
• pyruvate carboxylase deficiency
• pyruvate dehydrogenasedeficiency
• neonatal adrenoleukodystrophy
• infantile Refsum disease
• herediatry tyrosinemia
• Wilson disease
• organic acidurias
• urea cycle diseases

 hepatic storage diseases

 cirrhotic pattern (metabolic cirrhosis)

• hereidtary tyrosinemia
• galactosemia
• Wolman disease
• cerebrohepatorenal syndrome (Zellweger syndrome)
• glycogen storage disease type IV (GSD4)
• indian childhood cirhosis
• alpha-antitrypsin deficiency
• Wilson disease
• mitochondrial respiratory chain diseases
• neonatal adrenoleukodystrophy
• infantile Refsum disease
• familial cholestatic syndromes
• mucopolysaccharidoses
• sialidosis
• Gaucher disease
• Niemann-Pick diseases
• hemochromatosis

 tumoral pattern

• focal nodular hyperplasia
  • glycogen storage type I (GSD1)

• adenoma
  • glycogen storage type I (GSD1)

• hepatoblastoma
  • glycogen storage type Ia (GSD1a)

• regenerative nodule and hepatocellular carcinoma
  • tyrosinemia
  • glycogen storage type I (GSD1)
  • glycogen storage type Ia (GSD1a)
  • glycogen storage type IV (GSD4)
  • alpha-1-antitrypsin deficiency
  • hemochromatosis
  • galactosemia
  • familial cholestatic syndromes
  • Wilson disease
  • porphyria

References

 Jevon GP, Dimmick JE. Histopathologic approach to metabolic liver disease: Part 1. Pediatr Dev Pathol. 1998 May-Jun;1(3):179-99. PMID: #10463278#

 Jevon GP, Dimmick JE. Histopathologic approach to metabolic liver disease: Part 2. Pediatr Dev Pathol. 1998 Jul-Aug;1(4):261-9. PMID: #10463287#