Syntaxins function in the vesicle fusion process in the presynaptic active zone. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis.

Members

 syntaxin-1A (MIM.186590)
 syntaxin-1B (MIM.186590)
 syntaxin-2 (epimorphin) (MIM.132350)
 syntaxin-3 (MIM.600876)
 syntaxin-4 (MIM.186591)
 syntaxin-5 (MIM.603189)
 syntaxin-6 (MIM.603944)
 syntaxin-7 (MIM.603217)
 syntaxin-8 (MIM.604203)
 syntaxin-9 (MIM.)
 syntaxin-10 (MIM.603765)
 syntaxin-11 (MIM.605014)
 syntaxin-12 (MIM.606892) = syntaxin-13 (MIM.606892)
 syntaxin-14 (MIM.)

Pathology

 STX11 germline mutations in familial hemophagocytic lymphohistiocytosis type-4 (FHL4) (#15703195#)

See also

 syntaxins-containing vesicles
 syntaxins-binding proteins
 insintaxin transport