Cellular phenotypes are determined by the differential activity of networks linking coregulated genes.

References

 Basso K, Margolin AA, Stolovitzky G, Klein U, Dalla-Favera R, Califano A. Reverse engineering of regulatory networks in human B cells. Nat Genet. 2005 Apr;37(4):382-90. PMID: #15778709#

 Tosh D, Slack JM: How cells change their phenotype. Nat Rev Mol Cell Biol 3:187, 2002.