Dynamic regulation of chromatin structure is thought to be a prerequisite for nuclear functions that require accessibility to DNA such as replication, transcription and DNA repair.

Features

 chromatin structure
 chromatin packing
 chromatin remodelling and chromatin remodeling complexes
 chromatin dynamics
 chromatin assembly
 chromatin modifiers

Pathology (chromatin diseases)

 chromatin remodeling disorders

• Williams-Beuren syndrome
• rhabdoid tumor syndrome

 pathology of chromatin assembly

• Rett syndrome

References

 Croce LD. Chromatin modifying activity of leukaemia associated fusion proteins. Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R77-84. PMID: #15809276#

 Chandler VL, Stam M. Chromatin conversations: mechanisms and implications of paramutation. Nat Rev Genet. 2004 Jul;5(7):532-44. PMID: #15211355#

 Jones DR, Divecha N. Linking lipids to chromatin. Curr Opin Genet Dev. 2004 Apr;14(2):196-202. PMID: #15196467#

 Bickmore WA, van der Maarel SM. Perturbations of chromatin structure in human genetic disease: recent advances. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R207-13. PMID: #12915455#

 Hendrich B, Bickmore W. Human diseases with underlying defects in chromatin structure and modification. Hum Mol Genet. 2001 Oct 1;10(20):2233-42. PMID: #11673406#