rapidly involuting congenital hemangioma (RICH)

RICH and NICH had many similarities, such as appearance, location, size, and sex distribution. The obvious differences in behavior served to differentiate RICH, NICH, and common infantile hemangioma. Magnetic resonance imaging (MRI) of the three tumors is quite similar, but some RICH also had areas of inhomogeneity and larger flow voids on MRI and arterial aneurysms on angiography. The histologic appearance of RICH differed from NICH and common infantile hemangioma, but some overlap was noted among the three lesions.

Synopsis

 small-to-large lobules of capillaries
 moderately plump endothelial cells and pericytes
 lobules surrounded by abundant fibrous tissue.

 central involuting zone(s) characterized by lobular loss, fibrous tissue, with large and abnormal draining channels (50%)
 hemosiderin thrombosis
 cyst formation
 focal calcification
 extramedullary hematopoiesis

Immunochemistry

 With rare exceptions, endothelial cells in RICH (as in NICH) did not express glucose transporter-1 protein (GLUT1)

See also

 vascular tumors

• congenital hemangioma
  • NICH (non-involuting congenital hemangioma)

References

 Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, Burrows PE, Perez-Atayde AR, Kozakewich HP. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003 Nov-Dec;6(6):495-510. PMID: #15018449#