epithelioid hemangioma
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Epithelioid hemangioma is an uncommon vascular tumefaction of uncertain pathogenesis. Past terminology used to describe this process includes atypical or pseudopyogenic granuloma, inflammatory angiomatous nodule, angioblastic (lymphoid) hyperplasia with eosinophilia, angiolymphoid hyperplasia with eosinophilia, intravenous atypical vascular proliferation, and histiocytoid hemangioma.
The anatomic sites most frequently affected by epithelioid hemangioma are the head (in the distribution of the superficial temporal artery) and the distal portions of the extremities, especially the digits.
Localization
soft tissue epithelioid hemangioma
penile epithelioid hemangioma (15087672)
Synopsis
proliferation of epithelioid endothelial cells
nodular or lobular configuration
inflammatory infiltrate containing lymphocytes and eosinophils
associated with a small arterial segment
- mural damage
- intraluminal epithelioid endothelial cells
Immunohistochemistry
CD31 +
factor VIIIrAg +
CD34 +
+/- keratins
+/- focal muscle-specific actin-positive myopericytic cells
Differential diagnosis
epithelioid vascular tumors
- epithelioid hemangioendothelioma
- epithelioid angiosarcoma
See also
Vascular tumors