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ubiquitin

 

Function

-  Ubiquitin modifications target proteins to the 26S proteasome for proteolysis.
-  polyubiquitin (polyUb) chains promote proteasomal degradation
-  monoubiquitin (monoUb) play a role in vesicular trafficking

Types

-  polyubiquitin (polyUb)
-  monoubiquitin (monoUb)

Pathology of ubiquitin

-  ubiquitin-positive deposits found in patients with Alzheimer's disease (AD)

See also

-  ubiquitin-positive deposits

References

-  Sun L, Chen ZJ. The novel functions of ubiquitination in signaling. Curr Opin Cell Biol. 2004 Apr;16(2):119-26. PMID: #15196553#

-  Ohta T, Fukuda M. Ubiquitin and breast cancer. Oncogene. 2004 Mar 15;23(11):2079-88. PMID: #15021895#

-  Hegde AN, DiAntonio A. Ubiquitin and the synapse. Nat Rev Neurosci. 2002 Nov;3(11):854-61. PMID: #12415293#

-  Buchberger A. From UBA to UBX: new words in the ubiquitin vocabulary. Trends Cell Biol. 2002 May;12(5):216-21. PMID: #12062168#

-  Hicke L. Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol. 2001 Mar;2(3):195-201. PMID: #11265249#

-  Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 2000 Oct;10(10):429-39. PMID: #10998601#

-  Jentsch S, Pyrowolakis G. Ubiquitin and its kin: how close are the family ties? Trends Cell Biol. 2000 Aug;10(8):335-42. PMID: #10884686#

-  Lowe J, Mayer RJ, Landon M. Ubiquitin in neurodegenerative diseases. Brain Pathol. 1993 Jan;3(1):55-65. PMID: #8269084#

-  Mayer RJ, Lowe J, Lennox G, Doherty F, Landon M. Intermediate filaments and ubiquitin: a new thread in the understanding of chronic neurodegenerative diseases. Prog Clin Biol Res. 1989;317:809-18. PMID: #2557642#

-  Ohta M, Marceau N, Perry G, Manetto V, Gambetti P, Autilio-Gambetti L, Metuzals J, Kawahara H, Cadrin M, French SW. Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes. Lab Invest. 1988 Dec;59(6):848-56. PMID: #2462130#


Ubiquitin and the proteasome pathway

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