Members

Functions

 AMP-activated protein kinase (AMPK) plays a key role in the regulation of fatty acid and cholesterol metabolism. In vitro, it phosphorylates and inactivates 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)(MIM.142910) and acetyl-CoA carboxylase (ACC) (MIM.200350), key enzymes involved in regulating de novo biosynthesis of cholesterol and fatty acids, respectively.

References

 Barnes BR, Zierath JR. Role of AMP--activated protein kinase in the control of glucose homeostasis. Curr Mol Med. 2005 May;5(3):341-8. PMID: #15892653#

 Hardie DG. New roles for the LKB1-->AMPK pathway. Curr Opin Cell Biol. 2005 Apr;17(2):167-73. PMID: #15780593#