HSPG2 or perlecan is a form of heparan sulfate proteoglycan, a major component of basement membranes. Perlecan is encoded by a gene that maps to chromosome 1.
Heparan sulfate proteoglycan is a major component of basement membranes, where the molecule may be involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion.