basement membrane
basal lamina, basa lmembrane
The basement membranes are a specialized extracellular matrix underlying all epithelia, endothelia and surrounding muscle, adipose and Schwann cells. Im the embryo, the basal membrane is the first organized extracellular matrix to appear, underlying the trophodermal epithelia in the blastocyst.
Major constituents
laminin
collagen IV
perlecan
nidogen
Pathology of basal membranes
References
Kalluri R. Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer. 2003 Jun;3(6):422-33. PMID: #12778132#
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