WNT signaling pathway
Wnt signaling, Wnt/beta-catenin signaling
Components
| WNT1 | CTNNB1 | AXIN1 | AXIN2 |
Members
Wnt/beta-catenin pathway
Pathology of the Wnt/beta-catenin pathway
cancer predisposition
- colonic cancer predisposition
mutations in AXIN2 predispose to colonic adenocarcinoma (#15042511#)
- mutations in AXIN2 in familial tooth agenesis (#15042511#)
References
Wang J, Wynshaw-Boris A. The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation. Curr Opin Genet Dev. 2004 Oct;14(5):533-9. PMID: #15380245#
Tolwinski NS, Wieschaus E. Rethinking WNT signaling. Trends Genet. 2004 Apr;20(4):177-81. PMID: #15041171#
Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 2004 Mar 5;303(5663):1483-7. PMID: #15001769#
Kalderon D. Similarities between the Hedgehog and Wnt signaling pathways. Trends Cell Biol. 2002 Nov ;12(11):523-31. PMID : #12446114#
Kuhl M, Sheldahl LC, Park M, Miller JR, Moon RT. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 2000 Jul;16(7):279-83. PMID: #10858654#
Nusse R. WNT targets. Repression and activation. Trends Genet. 1999 Jan ;15(1):1-3. PMID : #10087922#
WNT signaling pathway - From Biocarta
beta-catenin and cadherin pathway - From Biocarta