Vascular transformation of lymph node sinuses (VTS) is characterized by conversion of nodal sinuses into capillary-like channels, often accompanied by fibrosis.

The vasoproliferative process caused variable expansion of the subcapsular, intermediate, and medullary sinuses of the lymph nodes and involved single or multiple lymph nodes in a diffuse or segmental fashion.

The proliferated vessels formed anastomosing narrow clefts, rounded spaces of different sizes, plexiform channels, or solid spindled to plump cellular foci and often were associated with variable degrees of sclerosis.

Synopsis

 empty vascular spaces filled with lymph-like fluid, congested with blood, or occasionally thrombosed
 extravasation of red cells
 perivascular fibrin deposition
 eosinophilic globules
 vascular thrombosis in extranodal vessels

Differential diagnosis

 Kaposi sarcoma