PIK3CA
PI3K subunit p110alpha (PIK3CA) is a subunit of PI3Ks. The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation.
PI3KCA is one of the most commonly mutated oncogenes in human cancer.
somatic mutations in PIK3CA gene (kinase domain ++) in:
- colorectal adenocarcinoma
- mammary carcinomas (25%) (#15254419#)
- gastric adenocarcinoma (#15784156#)
- ovarian carcinomas
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