ADP-ribosylation factor (ARF)-like-6 (ARL6) is a member of a subgroup of the ARF family, proteins that regulate diverse cellular functions, including regulation of intracellular traffic. The ARF group of proteins is part of the Ras superfamily, which is subdivided into ARFs and ARF-like (ARLs) subgroups.

Function

 ARF6 (BBS3) is a member of the ARF family of small GTP-binding proteins that regulate vesicle trafficking. In C. elegans, BBS-3 localizes to the cytoplasm, transition zone (basal body) and cilia of ciliated sensory neurons and undergoes IFT, thereby offering a possible direct link between axonemal and cytoplasmic transport of specific cargo.

Pathology

 Gerline mutations in ARL6 in Bardet-Biedl syndrome (BBS3).