RASSF1A tumor suppressor functions as a regulator of the ordered proteolytic steps that organize mitosis. By controlling the stability of microtubules and the activity of the anaphase-promoting complex (APC), RASSF1A might provide a crucial link between mechanisms of tumor suppression and mitotic cell division.

References

 Jackson PK. Linking tumor suppression, DNA damage and the anaphase-promoting complex. Trends Cell Biol. 2004 Jul;14(7):331-4. PMID: #15246424#