D2-40 is a monoclonal antibody recognizing a 40 000 kD O-linked sialoglycoprotein located in lymphatic endothelial cells. This oncofetal antigen is present in fetal germ cells.

Expression in normal cells

 endothelium of lymphatic channels

Expression in tumors

 Kaposi sarcoma
 lymphangiomas
 benign tumors of lymphatic origin

• Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) (#15059220#)

 epithelioid malignant mesothelioma (86%) (#15891998#)
 angiosarcoma (40%) (#15891998#)

Negative tumors

 hemangiomas
 glomus tumors
 angiolipomas
 pyogenic granuloma
 vascular malformations
 hemangiopericytoma
 hemangioendothelioma

See also

 O-linked sialoglycoprotein

References

 Debelenko LV, Perez-Atayde AR, Mulliken JB, Liang MG, Archibald TH, Kozakewich HP. D2-40 immunohistochemical analysis of pediatric vascular tumors reveals positivity in kaposiform hemangioendothelioma. Mod Pathol. 2005 Nov;18(11):1454-60. PMID: #15920541#

 Roy S, Chu A, Trojanowski JQ, Zhang PJ. D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas. Acta Neuropathol (Berl). 2005 May;109(5):497-502. PMID: #15864611#

 Hornick JL, Fletcher CD. Intraabdominal cystic lymphangiomas obscured by marked superimposed reactive changes: clinicopathological analysis of a series. Hum Pathol. 2005 Apr;36(4):426-32. PMID: #15892005#

 Ordonez NG. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol. 2005 Apr;36(4):372-80. PMID: #15891998#

 Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology. 2005 Apr;46(4):396-402. PMID: #15810951#

 Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi sarcoma and a subset of angiosarcomas. Mod Pathol. 2002 Apr;15(4):434-40. PMID: #11950918#