Cytogenetics

 clonal chromosomal abnormalities (76%)

• 4 subgroups according to ploidy status
• pseudodiploid (16%)
• hypodiploid (47%)
• hyperdiploid (19%)
• 18% mixed cases associating 2 different clones (hypodiploid + hyperdiploid) or (pseudodiploid + hyperdiploid)

 Complex rearrangements and hypodiploid chromosome number (50%)

• partial or entire monosomies (56%)
• Chr.5
• Chr.7
• Chr.8
• Chr.16
• Chr.21

 BCR-ABL fusion in pure erythroid" leukemia (57%)

refractory anemia with excess of blasts in transformation (RAEB-t)

References

 Lessard M, Struski S, Leymarie V, Flandrin G, Lafage-Pochitaloff M, Mozziconacci MJ, Talmant P, Bastard C, Charrin C, Baranger L, Helias C, Cornillet-Lefebvre P, Mugneret F, Cabrol C, Pages MP, Fert-Ferret D, Nguyen-Khac F, Quilichini B, Barin C, Berger R, The Groupe Francais d'Hematologie Cellulaire Gfhc; on behalf of the Groupe Francophone de Cytogenetique Hematologique (GFCH). Cytogenetic study of 75 erythroleukemias. Cancer Genet Cytogenet. 2005 Dec;163(2):113-22. PMID: #16337853#