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inhibitors of apoptosis

IAPs, caspases inhibitors

 

Group of proteins that demonstrate significant inhibition of apoptosis and caspases.

Members

BIRC1 BIRC2 BIRC3 BIRC4 BIRC5 BIRC6 BIRC7
HIAP1 HIAP2

XIAP, HIAP1 (601721), and HIAP2 (601712) belong to a human multigene family whose members show extensive homology to baculovirus IAPs (inhibitor of apoptosis proteins) and encode proteins that demonstrate significant inhibition of apoptosis.

References

-  Andersen MH, Becker JC, Straten P. Regulators of apoptosis: suitable targets for immune therapy of cancer. Nat Rev Drug Discov. 2005 May;4(5):399-409. PMID: #15864269#

-  Senderowicz AM. Targeting cell cycle and apoptosis for the treatment of human malignancies. Curr Opin Cell Biol. 2004 Dec;16(6):670-8. PMID: #15530779#

-  Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004 Oct 15;64(20):7183-90. PMID: #15492230#



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