Cytogenetics: #7889500#
add(1)(q42)
t(13;22)(q10;q10) (#7889500#)
t(13;13)(q10;q10), i(6p)(p10), and del(1) (#7889500#)
Molecular biology
11p LOH (86%) (#12116082#, #11696422#)
IGF2 overexpression (#12116082#)
activating mutations of the beta-catenin gene CTNNB1 (67%) (#11696422#)
germline truncating mutation combined with loss of the wild-type allele in familial adenomatous polyposis-associated pancreatoblastoma (#11696422#)
Predisposition
Beckwith-Wiedemann syndrome
familial adenomatous polyposis (FAP)
References
Klimstra DS, Wenig BM, Adair CF, Heffess CS. Pancreatoblastoma. A clinicopathologic study and review of the literature. Am J Surg Pathol. 1995 Dec;19(12):1371-89. PMID: #7503360#