Sacrococcygeal teratoma (SCT) is the most common tumor of the newborn with an incidence of 1 in 35,000 to 40,000 live births. In the newborn, the sacrococcygeal site is located at the base of the tailbone (coccyx), is the most common location of teratomas in newborns.

Cytogenetics

 constitutional partial monosomy 7q (#14663834#)
 constitutional trisomy 2p (#14663834#)
 constitutional t(12;15)(q13;q25) pat (#12165446#)

• MESDC2/SENP1 fusion gene (#15917269#)

Predisposition

 Currarino syndrome

• presacral teratoma
• anterior meningocele
• sacral agenesis
• anorectal malformation

 constitutional t(12;15)(q13;q25) pat (#12165446#)

• MESDC2/SENP1 fusion gene (#15917269#)

References

 Sebire NJ, Fowler D, Ramsay AD. Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases. Fetal Pediatr Pathol. 2004 Sep-Dec;23(5-6):295-303. PMID: #16137166#

 Heerema-McKenney A, Harrison MR, Bratton B, Farrell J, Zaloudek C. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005 Jan;29(1):29-38. PMID: #15613854#

 Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group. Am J Surg Pathol. 1998 Sep;22(9):1115-24. PMID: #9737245#