The ubiquitous beta-arrestin molecules play important roles in the endocytosis and signaling of these receptors. These functions reflect the ability of the beta-arrestins to bind signaling and endocytic elements, often in an agonist-dependent fashion.

 One of them is is leading to MAP kinase activation via beta-arrestin-mediated scaffolding of these pathways in a receptor-dependent fashion.

 The beta-arrestins are also involved in the regulation of novel receptor systems, such as Frizzled and TGFbeta receptors.

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References

 Lefkowitz RJ, Whalen EJ. beta-arrestins: traffic cops of cell signaling. Curr Opin Cell Biol. 2004 Apr;16(2):162-8. PMID: #15196559#