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capillary hemangioblastoma

 

Capillary hemangioblastoma (CH) is a tumor of unknown histogenesis that arises primarily in the posterior cranial fossa, either as a sporadic event or in association with von Hippel-Lindau disease (VHL).

Molecular biology

-  3p25 LOH: VHL locus (#15535134#)
-  6q LOH (#15535134#, #11943349#)
-  22q13 LOH (#15343513#)

References

-  Patton KT, Satcher RL Jr, Laskin WB. Capillary hemangioblastoma of soft tissue: report of a case and review of the literature. Hum Pathol. 2005 Oct;36(10):1135-9. PMID: #16226115#

-  Roy S, Chu A, Trojanowski JQ, Zhang PJ. D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas. Acta Neuropathol (Berl). 2005 May;109(5):497-502. PMID: #15864611#

-  Michal M, Vanecek T, Sima R, Mukensnabl P, Boudova L, Brouckova M, Koudepa K. Primary Capillary Hemangioblastoma of Peripheral Soft Tissues. Am J Surg Pathol. 2004 Jul;28(7):962-966. PMID: #15223969#



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