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parosteal osteosarcoma

juxtacortical osteosarcoma

 

Parosteal osteosarcomais a distinctive type of osteosarcoma that originates on the external surface of bone specifically in relation to the periostum or the immediate parosteal connective tissue or both.

Macroscopical synopsis

-  hard, white, dense bone with frequent, small, peripheral, satellite nodules
-  areas of fat or fibrous tissue interspersed within the lesion or in the clefts between satellites.
-  areas of dedifferentiation appear soft and fleshy.
-  amorphous, heavy trabeculae of disorganized bone admixed with dense, white, fibrous connective tissue.

Microscopical synospsis

-  repetitive pattern of heavy trabeculae containing "Pagetoid" cement lines
-  monotonous stroma of mature, spindle cells without cytologic atypia.
-  nuclei of the stroma tend to be arranged parallel to each other and give the appearance of a "school of fish".
-  areas of higher-grade osteosarcoma are rare and may be minute.
-  mature, nonstress-oriented trabeculae are enmeshed in stroma of well-differentiated spindle cells.
-  low cell-matrix ratio in the spindle cell stroma. The cells have a monotonous pattern resembling a school of fish swimming along a reef.
-  long axis of the cells are parallel, there is no cellular atypia or mitoses and each cell looks exactly like the next.
-  irregular, heavy cement lines in the neoplastic trabeculae and the low cell-to-matrix ratio in the stromal cells. low
-  hyperchromatic spindle cells

Subtypes

-  dedifferentiated parosteal osteosarcoma


Parosteal osteosarcoma infiltrating muscles

Parosteal osteosarcoma infiltrating muscles

Parosteal osteosarcoma

Parosteal osteosarcoma

Parosteal osteosarcoma infiltrating muscles

Parosteal osteosarcoma infiltrating muscles
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