osteosarcomas
osteosarcomas, osteogenic sarcoma
Microscopical variants
conventional osteosarcoma
chondroblastic osteosarcoma
telangiectatic osteosarcoma
Topographic variants
parosteal osteosarcoma (juxtacortical osteosarcoma)
Localization
ilac osteosarcoma
femoral osteosarcoma
Etiology
Loci ivolved
| 3q26 | |
| 4q32-q34 | |
| 13q14.1-q14.2 | RB |
| 17p13.1 | TP53 |
| 18q22 | DCC |
Oncogenes overexpression
Gene amplification
| MDM2 | 5-10% |
| HER2 | 40% |
References
Sandberg AA, Bridge JA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors. Cancer Genet Cytogenet. 2003 Aug;145(1):1-30. PMID: #12885459#
AGCOH - Atlas of Genetics and Cytogenetics in Oncology and Haematology
Parosteal osteosarcoma infiltrating muscles
Parosteal osteosarcoma
Parosteal osteosarcoma
Parosteal osteosarcoma infiltrating muscles
Parosteal osteosarcoma infiltrating muscles
Femoral osteosarcoma
Femoral osteosarcoma
Iliac osteosarcoma
Iliac osteosarcoma
Iliac osteosarcoma
Femoral osteogenic osteosarcoma
Femoral osteogenic osteosarcoma
Femoral osteogenic osteosarcoma
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