Mechanisms

 fusion gene in which the promoter region of a first gene is juxtaposed to the entire coding sequence of a second gene that is subsequently overexpressed in specific tissue

• Exemple: fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence on 17p13 with USP6 overexpression in aneurysmal bone cyst (#15026324#)