Function

SKI is a component of the TGFB1 signaling pathway.

TGFB1 (MIM.190180) induces phosphorylation and nuclear translocation of SMAD3 (MIM.603109). SMAD3 associates with the nuclear protooncogene protein SKI in response to the activation of TGFB1 signaling.

Association with SKI repressed transcriptional activation by SMAD3, and overexpression of SKI rendered cells resistant to the growth-inhibitory effects of TGFB1.

The transcriptional repression as well as the growth resistance to TGFB1 by overexpression of SKI could be overcome by overexpression of SMAD3.

Features

 SKI-related gene SNO (MIM.165340)
 SMADs
 TGF-beta signaling pathway

References

 Luo K. Ski and SnoN: negative regulators of TGF-beta signaling. Curr Opin Genet Dev. 2004 Feb;14(1):65-70. PMID: #15108807#