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malignant fibrous histiocytoma

MFH

 

Malignant fibrous histiocytomas (MFHs) are aggressive tumors without any definable line of differentiation.

Genetic finding are similar to that in well-differentiated liposarcomas, strongly suggests that these tumors actually correspond to undifferentiated liposarcomas.

Cytogenetics

-  amplifications of the 12q14-q15 chromosome region (20%)
-  1p32 band amplification
-  6q23 band amplification (amplification and overexpression of ASK1 or MAP3K5 gene)

Molecular biology

-  amplification and overexpression of ASK1 or MAP3K5 gene at 6q23 band (#15034865#)

Differential diagnosis

-  dedifferentiated liposarcomas (#15221942#, #12640106#)

References

-  Chibon F, Mariani O, Derre J, Mairal A, Coindre JM, Guillou L, Sastre X, Pedeutour F, Aurias A. ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications. Genes Chromosomes Cancer. 2004 May;40(1):32-7. PMID: #15034865#

-  Chibon F, Mariani O, Derre J, Malinge S, Coindre JM, Guillou L, Lagace R, Aurias A. A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas. Cancer Genet Cytogenet. 2002 Nov;139(1):24-9. PMID: #12547153#


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