Epidemiology:

 mostly sporadic
 rare familial occurence (#11115185#)

Microscopical synopsis:

 biphasic growth pattern
 dilated vascular structures in the superficial dermis lined by prominent hobnail endothelial cells
 collagen dissecting, rather narrow neoplastic vessels in deeper parts of the lesion

Immunochemistry:

 CD31 + (100%) (#10472756#)
 CD34 +/- (8%) (#10472756#)
 VEGFR-3 (50%) (#10472756#)

Differential diagnosis:

 cavernous lymphangioma
 lymphangioma circumscriptum
 retiform hemangioendothelioma
 progressive lymphangioma
 Dabska's tumor

Return to: vascular tumors

References: #3170814#, #1498402#, #2118554#, #10472756#