Phosphoinositides (PIs) play an essential role in diverse cellular functions. Their intracellular level is strictly regulated by specific phosphoinositides kinases, phosphoinositides phosphatases and phosphoinositides phospholipases.

Members

 3-phosphoinositide

Pathology

 phosphoinositide signaling diseases

• PTEN-associated diseases
• Src homology 2-containing inositol-5-phosphatase phosphatases in acute myeloid leukemia or diabetes
• myotubularin family members in genetic diseases
• OCRL1 in Lowe syndrome

Features

 phosphoinositides signaling pathways

References

 Downes CP, Gray A, Lucocq JM. Probing phosphoinositide functions in signaling and membrane trafficking. Trends Cell Biol. 2005 May;15(5):259-68. PMID: #15866030#

 Jones DR, Divecha N. Linking lipids to chromatin. Curr Opin Genet Dev. 2004 Apr;14(2):196-202. PMID: #15196467#

 Pendaries C, Tronchere H, Plantavid M, Payrastre B. Phosphoinositide signaling disorders in human diseases. FEBS Lett. 2003 Jul 3;546(1):25-31. PMID: #12829232#