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HHV8-associated lymphoma

KSHV/HHV8-associated B-cell lymphomas

 

Synopsis

-  sinusoidal infiltrate
-  large B-cells
-  possible anaplastic cellular morphology
-  strong positivity for KSHV/HHV8 latency-associated nuclear antigen
-  PCR analysis: KSHV/HHV8 infection

Molecular bioogy

-  B-cell lineage with immunoglobulin heavy and kappa light chain gene rearrangements

Differential diagnosis

-  anaplastic large cell lymphoma (ALCL)



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