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acute fibrinous organizing pneumonia

AFOP pattern, acute fibrinous and organizing pneumonia

 

Lesions

-  intra-alveolar fibrin (alveolar fibrinous exudates)
-  organizing pneumonia (pulmonary organization)
-  type 2 pneumocyte hyperplasia
-  edema
-  acute inflammation and chronic inflammation (inflammatory infiltrate)
-  pulmonary interstitial widening

Associations

-  collagen vascular disease

-  amiodarone
-  Haemophilus influenza
-  Acinetobacter lymphomaairspray
-  severe acute respiratory syndrome (SARS) (#15272286#)
-  construction work
-  coal mining
-  zoological work

Differential diagnosis

-  organizing pneumonia

References

-  Beasley MB, Franks TJ, Galvin JR, Gochuico B, Travis WD. Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med. 2002 Sep;126(9):1064-70. PMID: #12204055#



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