Components: |SDHA|SDHB|SDHC|SDHD|

Pathology

 Leigh syndrome (SDHA)
 deficiency of complex II of mitochondrial respiratory chain (MIM.252011) (SDHA)
 susceptibility to head and neck paraganglioma (SDHB, SDHC, SDHD)
 familial and isolated phaeochromocytoma (SDHD and SDHB)
 early onset renal cell carcinoma (RCC) (SDHB)

References

 Rustin P, Munnich A, Rotig A. Succinate dehydrogenase and human diseases: new insights into a well-known enzyme. Eur J Hum Genet. 2002 May;10(5):289-91. PMID: #12082502#

 Baysal BE. On the association of succinate dehydrogenase mutations with hereditary paraganglioma. Trends Endocrinol Metab. 2003 Dec;14(10):453-9. PMID: #14643060#