Cytogenetics

 t(2;17)(p23;q23)

Molecular biology

In tumorigenesis, the ALK gene at 2p23 is known to be fused to NPM, TPM3, TPM4, TFG, ATIC, CLTC, MSN, and ALO17.

 ALK/NPM1 by t(2;5)(p23;q35) in ALCL
 ALK/TPM3 by t(1;2)(q25;p23)in IMF (MIM.191030)
 ALK/TPM4 by t(2;19)(p23;p13)in IMF
 ALK/TFG (TRK-fused gene) by t(2;3)(p23;q21) in ALCL (#10556217#)
 ALK/ATIC by inv(2)(p23q35) in IMF (#12939746#)
 ALK/CLTC (17q23): ALK/CLTC fusion gene (involving the clathrin gene - CLTC) by t(2;17)(p23;q23) in anaplastic large-cell lymphoma (ALCL), diffuse large B-cell lymphoma (DLBCL) and inflammatory myofibroblastic tumor (IMF)
 ALK/MYH9 (22q11.2) by t(2;22)(p23;q11.2) in anaplastic large cell lymphoma (#12800156#)
 ALK/MSN (moesin) by t(2;X)(p23;q11) in ALCL
 ALK/ALO17 by t(2;17)(p23;q25)in ALCL (#12112524#)
 ALK/CARS by t(2;11;2)(p23;p15;q31) in IMT (#12112524#)
 ALK/RANBP2 (2q13) : Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor (#12661011#) at 2q11-q13 by t(2;2)(p23;q13)