lysophosphatidic acid
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors.
Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis.
References
Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer. 2003 Aug;3(8):582-91. PMID: #12894246#
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