Pathology

 ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25)

• congenital fibrosarcoma (#9462753#)
• mesoblastic nephroma (#9811336#, #9823307#)
• chronic myeloid leukemia
• secretory breast carcinoma (#15101049#)

Bioogy

 chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation (#11751416#)

 ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation (#12173038#)

References

 Bourgeois JM, Knezevich SR, Mathers JA, Sorensen PH. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol. 2000 Jul;24(7):937-46. PMID: #10895816#