Variants
epithelioid Ewing sarcoma
spindle cell Ewing sarcoma
atypical pleomorphic extraosseous Ewing sarcoma
Localization
skeletal Ewing sarcoma (osseous Ewing sarcoma)
extraskeletal Ewing sarcoma (extraosseous Ewing sarcoma)
Immunochemistry
Cytogenetics and molecular biology
t(11;22)(q24;q12) (EWSR1/FLI1 fusion gene) (85%) (11q24 and 22q12)
t(21;22)(q22;q12) (EWSR1/ERG fusion gene) (21q22 and 22q12)
t(2;22)(q36; q12) (EWSR1/FEV fusion gene) (2q36 and 22q12)
t(17;22)(q21;q12) (EWSR1/ETV4 fusion gene) (17q21 and 22q12)
t(16;21)(p11;q22) (FUS/ERG fusion gene) (#1290763#) (16p11 and 22q12)
Imbalance
Gains | 1q+ | 8+ | 12+ |
See also
Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET)or "Ewing family of tumors" (EFTs)