Pathology

 germline mutations in the PRKAR1A gene coding for the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A

• Carney complex type 1
• primary pigmented nodular adrenocortical disease (PPNAD) (MIM.160980) (#12424709#)
• familial cardiac myxomas (MIM.255960)

 somatic mutations in the PRKAR1A gene in

• sporadic adrenocortical tumor (#14500362#)

References

 Bossis I, Stratakis CA. PRKAR1A: Normal and abnormal functions. Endocrinology. 2004 Aug 26 PMID: #15331577#