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nephrotic syndrome

 

The nephrotic syndrome is characterized by massive proteinuria, which leads to hypoproteinemia/hypoalbunemia, hyperlipidemia with elevated cholesterols, triglycerides and other lipids, and edema.

Synopsis

-  minimal change glomerulopathy (+)
-  membranous glomerulopathy (+)
-  focal segmental glomerulosclerosis (+)
-  mesangioproliferative glomerulopathy (-)

Etiology

-  inherited nephrotic syndromes

-  paraneoplastic nephrotic syndrome (membranous glomerulonephritis 75%)

References

-  Salomon R, Gubler MC, Niaudet P. Genetics of the nephrotic syndrome. Curr Opin Pediatr. 2000 Apr;12(2):129-34. PMID: #10763762#


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