Etiology

 neonatal syncytial giant cell hepatitis
 infectious giant cell hepatitis

• viral hepatitis
  • cytomegalovirus hepatitis
  • rubella virus hepatitis
  • herpes simplex hepatitis
  • HPV
  • HHV-6 hepatitis
  • varicella hepatitis
  • coxsackievirus hepatitis
  • echovirus hepatitis
  • reovirus 3 hepatitis
  • parvovirus B19 hepatitis
  • HIV hepatitis
  • enterovirus hepatitis
  • paramyxovirus hepatitis
  • hepatitis A
  • hepatitis B
  • hepatitis C (rare)

• bacterial hepatitis
  • systemic bacterial sepsis
  • syphilis - syphilitic hepatitis
  • listeriosis hepatitis
  • tuberculosis (tuberculous hepatitis)

 parasitic hepatitis

• toxoplasmosis hepatitis

 cholestasis

• biliary atresia
• choledochal cyst
• bile duct paucity
• cystic fibrosis
• familial intrahepatic cholestatic syndromes
• bile acid synthetic disorders (inborn errors of bile acid synthesis)

 chromosomal anomalies

• trisomy 21
• trisomy 18
• monosomy X

 genetic metabolic disorders

• alpha-1-antitrypsin deficiency (1) -* galactosemia
• Niemann-Pick disease
• Gaucher disease
• mucolipidosis
• cerebrohepatorenal syndrome (Zellweger's syndrome)
• acute tyrosinemia

 giant cell hepatitis with autoimmune hemolytic anemia (GCHAIHA)
 autoimmune hepatitis type II (LKM1+)
 erythematosus lupus (systemic lupus) ¸

According to age

 neonatal giant cell hepatitis
 infantile giant cell hepatitis
 postinfantile giant cell hepatitis

Associations

 neonatal hemochromatosis
 autoimmune hemolytic anemia (GCHAIHA)

See also

 hepatocytic giant cell transformation