Degos disease is a rare systemic disorder that affects small and medium sized arteries, causing them to become blocked (occlusive arteriopathy).

Degos disease usually progresses through two stages. During the first stage, characteristic skin lesions appear that may last for a period of time ranging from weeks to years. The second stage of Degos disease is most frequently characterized by lesions in the small intestine, but other organs may also be affected. Major symptoms may include abdominal pain, diarrhea, and/or weight loss. Intestinal lesions may break through the wall of the bowel (perforation), a potentially life-threatening complication. The exact cause of Degos disease is unknown.