hepatocellular carcinoma
HCC
Etiology
Loci involved
3p22-p21, 7q31, 8p22-p21.3, 9p21.3-p21.2, 15q21.1-q22.2, 16p13.3, 17p13.1
somatic mutations of TP53 (MIM.191170)
somatic mutations of MET (MIM.164860) (juvenile type hepatocellular carcinoma)
anomalies of the WNT signaling pathway
Loss of heterozygosity (LOH)
Variants
sarcomatoid hepatocellular carcinoma
Predisposition
macroregenerative and dysplastic nodules (MDNs) are hepatocellular carcinoma (HCC) precursor lesions
Features
hepatocellular carcinogenesis
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