Pathology

 nodal tumor-forming accumulations of plasmacytoid monocytes in lymph nodes, bone marrow, skin

• myeloproliferative disorders
  • chronic myelomonocytic leukemia
  • acute myeloid leukemia (monosomy 7 in IPCs)
  • acute monocytic leukemia
  • unclassifiable chronic myeloproliferative
  • myeloproliferative/myelodysplastic disease

Immunochemistry

 CD68+
 CLA/HECA452+
 CD123+
 interferon-alpha (IFN-alpha) inducible protein MxA+
 B-cell oncogene TCL1+
 granzyme-B+
 CD56-

References

 Vermi W, Facchetti F, Rosati S, Vergoni F, Rossi E, Festa S, Remotti D, Grigolato P, Massarelli G, Frizzera G. Nodal and Extranodal Tumor-forming Accumulation of Plasmacytoid Monocytes/Interferon-producing Cells Associated With Myeloid Disorders. Am J Surg Pathol. 2004 May;28(5):585-595. PMID: #15105645#