gastric carcinoma
gastric cancer
Predisposition
Helicobacter infection
Genetic predisposition
10% of familial clustering
E-cadherin gene (CDH1) mutations
mismatch repair genes mutations
- MSH2
- MLH1
germline P53 mutations (Li-Fraumeni syndrome)
References
Tahara E. Genetic pathways of two types of gastric cancer. IARC Sci Publ. 2004;(157):327-49. PMID: #15055305#
Simpson AJ, Caballero OL, Pena SD. Microsatellite instability as a tool for the classification of gastric cancer. Trends Mol Med. 2001 Feb;7(2):76-80. PMID: #11286759#
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