Epithelioid sarcoma is a rare, malignant soft-tissue neoplasm occurring on the distal extremities of young adults.

Synopsis

 proliferation of rounded to plump, spindle-shaped cells with abundant eosinophilic cytoplasm around areas of necrosis

Differential diagnosis

 granulomatous inflammation

Variants

 proximal-type epithelioid sarcoma (#15078349#)

• pelvic and perineal areas
• young to middle-aged adults
• proliferation of epithelioid-like cells with rhabdoid features in the absence of a granuloma-like pattern
• immunohistochemistry: vimentin+, cytokeratin+, epithelial membrane antigen+, CD34+
• differential diagnosis: tumors with rhabdoid features, extrarenal malignant rhabdoid tumor