Aneurysmal bone cyst (ABC) is a locally aggressive osseous lesion that typically occurs during the first two decades of life.

Cytogenetics

 17p13 rearrangements (USP6)

• translocation t(1;17) creating TRAP150/USP6 fusion
• translocation t(3;17) creating ZNF9/USP6 fusion
• translocation t(6:17)(p21;p13) (#11764383#)
• translocation t(9;17) creating OMD/USP6 fusion
• translocation t(16;17)(q22;p13) creating CDH11/USP6 fusion
• translocation t(17;17) creating COL1A1/USP6 fusion

Molecular biology

 variant translocations upregulate USP6 transcription by promoter swapping with the genes ZNF9, COL1A1, TRAP150 and OMD (#15735689#)

• translocation t(1;17) creating TRAP150/USP6 fusion
• translocation t(3;17) creating ZNF9/USP6 fusion
• translocation t(6:17)(p21;p13) (#11764383#)
• translocation t(9;17) creating OMD/USP6 fusion
• translocation t(16;17)(q22;p13) creating CDH11/USP6 fusion
• translocation t(17;17) creating COL1A1/USP6 fusion

 fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence on 17p13 (#15026324#, #15509545#)

Association

 chondroblastoma (#15704086#)

Differential diagnosis

 osseous giant cell tumor
 giant cell reparative granuloma (giant cell reaction)
 simple bone cyst
 telangiectatic osteosarcoma