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SARS

 

Synopsis

-  exudative phase of acute lung injury

-  diffuse alveolar damage pattern of acute lung injury
-  acute fibrinous organizing pneumonia pattern (AFOP pattern)
-  squamous metaplasia
-  scattered multinucleate giant cells
-  vascular fibrin thrombi
-  pulmonary infarcts
-  vascular endothelial damage of both small- and mid-sized pulmonary vessels

Complications

-  invasive fungal disease

-  cytomegalovirus infection

References

-  Stadler K, Rappuoli R. SARS: Understanding the Virus and Development of Rational Therapy. Curr Mol Med. 2005 Nov;5(7):677-97. PMID: #16305493#

-  Hwang DM, Chamberlain DW, Poutanen SM, Low DE, Asa SL, Butany J. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol. 2005 Jan;18(1):1-10. PMID: #15272286#

-  Peiris JS, Guan Y, Yuen KY. Severe acute respiratory syndrome. Nat Med. 2004 Dec;10(12 Suppl):S88-97. PMID: #15577937#

-  Peiris JS, Yuen KY, Osterhaus AD, Stohr K. The severe acute respiratory syndrome. N Engl J Med. 2003 Dec 18;349(25):2431-41. PMID: #14681510#

-  Drosten C, Preiser W, Gunther S, Schmitz H, Doerr HW. Severe acute respiratory syndrome: identification of the etiological agent. Trends Mol Med. 2003 Aug;9(8):325-7. PMID: #12928032#

-  Chan HL, Tsui SK, Sung JJ. Coronavirus in severe acute respiratory syndrome (SARS). Trends Mol Med. 2003 Aug;9(8):323-5. PMID: #12928031#



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