Synopsis

 intestinal villous atrophy
 increase of intraepithelial lymphocytes
 intestinal crypt hyperplasia
 chorionic lymphoplasmocytic infiltration

Differential diagnosis

 other causes of intestinal villous atrophy
 enteropathy-type T-cell lymphoma

Associations

 autoimmune diabetes
 autoimmune hepatitis
 systemic autoimmune disorders (#16133974#)

Predisposition

 HLA class II genes explain 40% of the heritable risk.
 non-HLA genes accounting for most of the familial clustering

• MYO9B gene variant (#16282976#)

See also

 refractory sprue
 enteropathy-associated T-cell lymphoma

References

 Sollid LM, Jabri B. Is celiac disease an autoimmune disorder? Curr Opin Immunol. 2005 Dec;17(6):595-600. PMID: #16214317#

 Treem WR. Emerging concepts in celiac disease. Curr Opin Pediatr. 2004 Oct;16(5):552-9. PMID: #15367850#

 Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med. 2002 Jan 17;346(3):180-8. PMID: #11796853#

 Vogelsang H, Schwarzenhofer M, Oberhuber G. Changes in gastrointestinal permeability in celiac disease. Dig Dis. 1998 Nov-Dec;16(6):333-6. PMID: #10207217#

 McManus R, Kelleher D. Celiac disease--the villain unmasked? N Engl J Med. 2003 Jun 19;348(25):2573-4. PMID: #12815145#

 Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med. 2002 Jan 17;346(3):180-8. PMID: #11796853#